Home » What is the Main Cause of Erectile Dysfunction?

What is the Main Cause of Erectile Dysfunction?

Erectile dysfunction causes can be relational, Physical organic, or psychological. 

Impotence is that you can’t get or keep an erection enough to have sexual intercourse.

You get an erection when blood accumulates in the shaft of your penis.

For that reason, the main physical causes of erectile dysfunction are strongly associated with blood flow.

That is why the major medical cause of erectile dysfunction is vascular disease.

This post covers the complete information on the main causes of erectile dysfunction.

The main causes of erectile dysfunction are:

1 | Atherosclerotic disease

Atherosclerotic disease is the cause of erection problems in men over 50 years up to 40%.

Atherosclerosis is a condition in which plaque is developed inside your arteries.

Those plaques are mostly made of cholesterol and fat.

They can cause harder and narrower arteries eventually.

Then the supply of blood to your organs decreases.

2 | Neurologic [ Nerve damage ]

Ed in men can be neurological. That is an inability to get or keep an erection. 

This type of erectile disorder is because of central, peripheral neurologic impairment.[4]

3 | psychological factors

Epidemiologic studies show that anxiety, depression, poor self-esteem, and stress can play a significant role in erection difficulty.

For that reason, learning how to manage stress and reduce anxiety can be an excellent help for ED treatments.[5]

4 | aging is one of the main cause of erectile dysfunction

Aging is one of the main causes of erectile dysfunction.

That is the risk of experiencing ED in men increases with age.

By getting older different factors can lead to age-related erection problems.

5 | diabetes

Studies show that diabetes can increase the risk of male erectile dysfunction over 50%.[7]

6 | hypertension

High blood pressure can result in ED. That is why erectile disorders are considered as symptoms of hypertension.[9]

7 | obesity

Some studies show that obesity is in connection with low testosterone and male erectile dysfunction.

So, losing some weight and having a healthy lifestyle can help increase sexual satisfaction and performance in men.

8 | hyperlipidemia

High-density lipoprotein (HDL) is one of the main causes of male erectile dysfunction, significantly in older men. 

Studies tell that hyperlipidemia and high blood cholesterol are related to erection difficulty.[11]

9 | testosterone deficiency

A decline in testosterone deficiency can increase the severity of ED in men.

Testosterone is essential to increase the production of nitric oxide synthase and phosphodiesterase type 5 that are crucial enzymes for having an erection.[13]

10 | Medications and tobacco

Antidepressants and tobacco uses are the most conventional medicines and substances that can give rise to ED in men.

Studies show that antidepressant medicines can have adverse effects on sexual dysfunction, life quality, relationships, and psychological health.[14]


References:

  1. Wyllie M. G. (2005). The underlying pathophysiology and causes of erectile dysfunction. Clinical cornerstone, 7(1), 19–27. https://doi.org/10.1016/s1098-3597(05)80045-6
  2. Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., Tan, R., Mulhall, J. P., & Hellstrom, W. J. (2016). Erectile dysfunction. Nature reviews. Disease primers, 2, 16003. https://doi.org/10.1038/nrdp.2016.3
  3. Tsujimura, A., Hiramatsu, I., Aoki, Y., Shimoyama, H., Mizuno, T., Nozaki, T., Shirai, M., Kobayashi, K., Kumamoto, Y., & Horie, S. (2017). Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men. Prostate international, 5(2), 65–69. https://doi.org/10.1016/j.prnil.2017.01.006
  4. Calabrò, R. S., Gervasi, G., Naro, A., de Luca, R., Marullo, M., & Bramanti, P. (2016). Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study. Innovations in clinical neuroscience, 13(1-2), 10–14.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896824/#:~:text=Neurologic%20ED%20can%20be%20broadly,and%2For%20peripheral%20neurologic%20impairment.
  5. Rosen R. C. (2001). Psychogenic erectile dysfunction. Classification and management. The Urologic clinics of North America, 28(2), 269–278. https://doi.org/10.1016/s0094-0143(05)70137-3
  6. Wang W. (2011). Zhonghua nan ke xue = National journal of andrology, 17(12), 1146–1151.
  7. Maiorino, M. I., Bellastella, G., & Esposito, K. (2014). Diabetes and sexual dysfunction: current perspectives. Diabetes, metabolic syndrome and obesity : targets and therapy, 7, 95–105. https://doi.org/10.2147/DMSO.S36455
  8. Corona, G., Mannucci, E., Mansani, R., Petrone, L., Bartolini, M., Giommi, R., Mancini, M., Forti, G., & Maggi, M. (2004). Aging and pathogenesis of erectile dysfunction. International journal of impotence research, 16(5), 395–402. https://doi.org/10.1038/sj.ijir.3901225
  9. Nunes, K. P., Labazi, H., & Webb, R. C. (2012). New insights into hypertension-associated erectile dysfunction. Current opinion in nephrology and hypertension, 21(2), 163–170. https://doi.org/10.1097/MNH.0b013e32835021bd
  10. Moon, K. H., Park, S. Y., & Kim, Y. W. (2019). Obesity and Erectile Dysfunction: From Bench to Clinical Implication. The world journal of men’s health, 37(2), 138–147. https://doi.org/10.5534/wjmh.180026
  11. Rao, K., Du, G. H., & Yang, W. M. (2006). Zhonghua nan ke xue = National journal of andrology, 12(7), 643–646.
  12. Roumeguère, T., Wespes, E., Carpentier, Y., Hoffmann, P., & Schulman, C. C. (2003). Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. European urology, 44(3), 355–359. https://doi.org/10.1016/s0302-2838(03)00306-3
  13. Blute, M., Hakimian, P., Kashanian, J., Shteynshluyger, A., Lee, M., & Shabsigh, R. (2009). Erectile dysfunction and testosterone deficiency. Frontiers of hormone research, 37, 108–122. https://doi.org/10.1159/000176048
  14. Higgins, A., Nash, M., & Lynch, A. M. (2010). Antidepressant-associated sexual dysfunction: impact, effects, and treatment. Drug, healthcare and patient safety, 2, 141–150. https://doi.org/10.2147/DHPS.S7634