Home » Best Over The Counter Pain Relievers | Which One Do You Need?

Best Over The Counter Pain Relievers | Which One Do You Need?

best over counter pain relievers list

Here we have brought together a list of best over the counter pain relievers to ease aches and pains. Click the link below to go straight to a specific section.

Table of content

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In general, there are two over the counter painkiller types. One type of pain relief medicine is acetaminophen. And another form of pain relief drugs is known as nonsteroidal anti-inflammatory drugs (NSAIDs).

People use pain relief products or pain management medication to relieve:

  • Headaches
  • Muscle aches (muscle soreness)
  • Arthritis and joint pain
  • Back pain
  • Neck pain
  • Diabetic neuropathy pain
  • Other pains or aches

People commonly use NSAIDs pain killing medicine to cure chronic pain like osteoarthritis and rheumatoid arthritis among adults.

Nonsteroidal anti-inflammatory drugs help block long-term pains and reduce inflammation and lower a high temperature (fever).

Also, acetaminophen is both a pain reliever and a fever reducer. This type of pain relief drugs help control or reduce mild to moderate pains like:

  • Headaches
  • Muscle aches
  • Menstrual periods
  • Colds
  • Sore throats
  • Toothaches
  • Backaches
  • Fever

Plus, other new painkiller types are cannabidiol CBD or hemp. People use hemp or CBD oil or cream to reduce pain like neuropathic pain and arthritis pain.

So, pain relievers do not treat a disease but help manage and control your pain.

From now on, you will find the best over the counter pain relievers on the market for various types of pain.

Strongest Over The Counter Pain Reliever

Basic Care Extra Strength Pain Relief | Best Acetaminophen Pill

Each Amazon Basic Care caplet gives 500 mg of acetaminophen, which makes it strong pain relievers and fever reducers. 

Adults can use this OTC pain killer medicine to reduce pains and aches temporarily, like:

  • The common cold
  • Headache
  • Backache
  • Slight pain of arthritis
  • Toothache
  • Muscular aches
  • Premenstrual and menstrual cramps
  • Fever

Price: as little as $0.02 per serving

Basic Care extra strength pain relief

Advil Liqui-Gels Pain Reliever and Fever Reducer

Advil Liqui-Gels is an NSAIDs pain killing product. Each solubilized capsule contains 200 mg of ibuprofen. So, it can be one of the strongest pain medications.

Ibuprofen is an NSAID for treating pain, fever, and inflammation.

Plus, Advil Liqui-Gels help fight pain at the source of inflammation. Also, it is liquid fast pain relief. So it works quickly to help get relief by targeting where it should go.

Also, it is fast absorption and gives quick relief that lasts long.

Long story short, people use Advil to relieve severe pains and aches like:

  • Headache
  • Lower back pain
  • Joint pain
  • Arthritis pain

Price: as little as $0.09 per serving

Advil Liqui-Gels pain reliever and fever reducer

Basic Care Naproxen Sodium Tablets

Each caplet gives 220 mg of naproxen sodium (NSAID). 

People use naproxen as strong pain medicine to relieve pains and aches, such as:

Plus, naproxen sodium is useful to reduce fever, stiff joints, and swelling.

Price: as little as $0.04 per serving

otc naproxen sodium tablets strong pain medicine

Tylenol Rapid Release Gels with Acetaminophen

Tylenol is one of the strongest pain relievers over the counter that gives 500 mg of acetaminophen.

Also, each gelcap gives quick and extra strength relief. It helps reduce temporary minor aches, pains and fever.

So, people use Tylenol rapid release gels to control and manage pains like;

  • Headache
  • Backache
  • Toothache
  • Cramps
  • Pain-related to the common cold

Price: as little as $0.10 per serving

Tylenol extra strength acetaminophen pain reliever and fever reducer

Percogesic Extra Strength | Best Aspirin Free Relief

It is best over the counter painkiller to reduce aches and pains caused by common colds, flu, and fever.

Each easy to swallow coated caplet contains 500 mg of acetaminophen as a pain reliever and fever reducer. Also, it gives 12.5 mg of diphenhydramine HCl. It is an antihistamine. 

Diphenhydramine helps relieve symptoms of allergy, the common cold, and hay fever. For instance, it helps reduce the rash, runny nose, itching, itchy eyes, nose, throat, watery eyes, cough, and sneezing.

Plus, users say it helps manage back pain, migraine headaches, and cramps. As well, some reported it is easy on the stomach.

Price: as little as $0.18 per serving

best over the counter painkiller and aspirin free relief

Aleve Liquid Capsules | Strength To Last 12 Hours

Each capsule contains 220 mg of naproxen sodium, which makes that the best otc painkiller that blocks pain for up to 12 hours.

Users reported fast relief and effective OTC NSAID to relieve minor pains like occasional headaches, joint pains, and muscle aches.

Plus, some reviews say it is more potent than Advil and last a long time.

Price: as little as $0.19 per serving

Aleve the best otc painkiller that blocks pain for up to 12 hours

Best Medicine For Arthritis Pain

Tylenol 8 Hour Arthritis Pain Tablets

Each caplet gives 650 mg of acetaminophen to make it the best pain reliever for joint pain.

As well as, it gives 2 layers of effective painkilling that work quickly to reduce minor arthritis and joint pain and last up to 8 hours.

Also, this oral pain reliever can help with:

  • Muscle aches
  • Backache
  • Headache
  • Toothache
  • The common cold
  • Premenstrual and menstrual cramps

Price: as little as $0.10 per serving

best oral arthritis pain relief

Top Pain Relief Creams

Best CBD Cream For Arthritis Pain

Ramina hemp extract contains a unique blend of hemp oil, aloe vera, turmeric, EMU oil, MSM, and arnica, which makes it one of the best topical pain relief cream.

Plus, this cream is fast-absorbing and long-lasting. Also, it is non-greasy that you can use it during the day and at night.

Also, it gives 60ml of hеmp еxtract to reduce:

  • Muscle aches
  • Back pains
  • Joint pain
  • Knee aches
  • Elbow pains
  • Arthritis pain

As well, it helps to soothe stiffness and inflammation. Plus, it claims to help with fibromyalgia and carpal tunnel pain, and pain in damaged nerves.

Price: as little as $12.95 

best cbd/hemp cream for arthritis pain

Best Leg Pain Relief Cream

Penetrex and Nuturna Neuropathy creams are two of the best pain relieving creams.

They contain Arnica Montana Flower Extract, MSM, and vitamin B6 to cure leg pains such as pain in your feet and leg cramps.

Also, you can use these pain relief products with other complementary therapies to ease leg pains.

Plus, they increase blood flow to the legs and are designed to hydrate and warm up your feet.

Price: Nuturna Neuropathy $8.32 /Ounce 

Penetrex $9.48 / Ounce

best leg pain relief cream
Penetrex pain relief for leg pain

Other Best Best Pain Relief Creams

  1. Voltaren arthritis pain gel is one of the best pain relief creams for topical arthritis pain.

It helps raise mobility and lower joint stiffness. Also, it is non-greasy and penetrates deep to block arthritis pain directly at the source.

You can apply for this pain relief topical cream on any joints like hands, elbows, ankles, wrists, knees, and etc.

2. Aspercreme with lidocaine is a maximum strength pain relief cream. It gives 4% lidocaine to target pain at the source. 

It is a topical numbing cream that relieves minor pains without causing any irritation or burning. 

Plus, it works in a couple of minutes and penetrates your muscles and joints deeply, and blocks the pain for hours by numbing.

So, you can use this pain reliever cream to ease minor pains caused by arthritis, or backaches, muscle strains, sprains and etc. plus, it is non-greasy odor-free.

Price: Voltaren arthritis pain gel $4.25 /Ounce 

Aspercreme $2.12 / Ounce

best pain relief creams
Aspercreme pain relieving creme with lidocaine

Best Natural Pain Relief Gel

Boiron Arnicare gel is a topical pain relief gel (ointment) that contains arnica montana.

It helps reduce muscle pain and joint stiffness caused by overexertion, minor injuries, or falls.

Plus, people use it for minor pains, bruises, and also swelling.

As well, it is water-based, non-greasy, and free of paraben, and absorbs quickly.

Price: as little as $3.07 / Ounce 

best natural pain relief gel

Best OTC Back Pain Relief

Aleve Back and Muscle Pain Tablets

Each blue tablet contains 220 mg of naproxen sodium to give muscle pain relief and ease backaches.

Aleve gives all day long pain relief that lasts 12 hours. It is a nonsteroidal anti-inflammatory drug (NSAID) that targets the source of pain.

Also, this pain relief remedy temporary reduce minor aches and pains such as:

  • Backaches
  • Muscular aches
  • Headaches
  • Minor arthritis (joint pain)
  • Menstrual pain
  • Toothaches

Plus, it can help reduce fever.

Price: as little as $0.11 per tablet  

best otc for muscle pain and back pain relief

Best Pain Reliever For Sciatica

Sciaticacare Nerve Pain Relief Supplement

It gives vitamins B1, B6, and B12, plus 80 mg of magnesium to regulate the biochemical reactions in muscles and nerves.

Also, it contains n-acetyl-l-carnitine that is turned to l-carnitine in the human body. This amino acid helps reduce nerve pain sciatica.

Price: as little as $0.58 per capsule  

best over the counter pain reliever for sciatica

Best Pain Relief Spray

Aspercreme Max Strength Dry Spray

It is an effective pain relief spray that contains 4% of lidocaine to numb pains and aches like muscle pain, back pain, and joint pain.

This spray painkiller works quickly. Plus, it does not have any odor and is non-greasy. As well, this stop pain spray dries immediately.

Price: as little as $2.22 / Ounce

fast pain relief spray

Best Aspirin Painkiller

Bc Powder | Fast Aspirin Pain Relief With Caffeine

Each pack gives 845mg of aspirin (nsaid) that make s it a strong pain reliever and fever reducer.

Plus, it contains 65 mg of caffeine 65mg to reduce pain sensation.

Also, users reported that it is a great pick to relieve headache and migraine.

Price: only $0.12 per pack

best aspirin pain killer

Best Pain Relieving Patch

Salonpas Pain Relieving Patch

Each pain-relieving patch contains 3.1% camphor, 6% menthol, and 10% methyl salicylate

These over counter patches for pain are easy to remove and last long for up to 8 hours to manage the pain.

Plus, these topical pain-relief patches help you to control pains and aches like:

  • Sore back
  • Neck
  • Wrist
  • Ankle
  • Hip
  • Shoulder
  • Knee
  • Elbow

Also, Salonpas patches alleviate backache, muscle soreness, sprains, and joint pain.

Price: only $0.16 / patch

best pain relieving patches

Best Children's Pain Reliever

Children's Motrin Oral Suspension Medicine for Kids

A teaspoon of this pain relief liquid contains 100 mg of ibuprofen to relieve pain or reduce fever in kids. 

Also, it reduces fever temporarily and relieves pain caused by the common cold and flu.

As well, it is in bubblegum. It means your child will take it happily.

Plus, users say that it works like a charm and acts shortly after the recommended dosage.

Price: as little as $1.49 / Fl Oz

best pain relief children

Best OTC Pain Reliever For Toothache

DenTek Instant Oral Pain Relief Kit for Toothaches

DenTek is one of the best remedies for toothache pain. It gives 20% benzocaine, plus peppermint oil, spearmint oil, and carbowax.

It helps you get relief from the grave toothaches quickly.

Plus, it helps relieve oral pains, such as: 

  • Sore gums
  • Mouth sores
  • Gum irritation
  • Canker sores
  • Cold sores
  • Braces irritation
  • Denture irritation

Price: as little as $0.16 /piece

best relief for toothache pain

Pain Reliever For UTI

AZO Urinary Pain Relief Maximum Strength

It is an OVER-THE-COUNTER UTI relief product that works FAST to reduce urinary pain.

Also, it helps to relieve urgency and burning in just 20 minutes.

Each tablet contains phenazopyridine hydrochloride. Pharmacists recommend it for urinary discomfort.

Price: only $12.89 

pain reliever for uti

Best Menstrual Cramps Pills [Reliever]

According to mayoclinic [1], the best pain relievers for menstrual cramps are listed below. You take them one day earlier when your period starts. It helps to manage cramp pains.

  • Advil ibuprofen
  • Motrin IB
  • Aleve naproxen sodium


    • Advil: only $0.07 per tablet 
    • Mortin IB: just $0.06 per caplet
    • Aleve naproxen: as little as $0.17 per tablet


Advil ibuprofen
Motrin IB
Aleve naproxen sodium